This study explores the relationship between college students’ personality traits and their perceptions of using ChatGPT. Twenty-three participants, who were enrolled in an Englishmedium instruction class participated in the study. They were asked to complete the Big Five Inventory, which examines one’s personality traits and a questionnaire gauging their perceptions of ChatGPT use. To analyze the data, correlation and frequency analyses were performed. The results of the correlation analysis revealed a robust correlation between conscientiousness and item 1 and between conscientiousness and item 3. In addition, an association was found between extraversion and item 5 and agreeableness and item 5. Furthermore, there was a strong relationship between conscientiousness and item 7 and between neuroticism and item 11. Regarding students’ perceptions of ChatGPT, the findings indicate a generally positive outlook on ChatGPT among students, particularly in enhancing grammar and vocabulary skills, and this is evidenced by self-reported improvements in writing abilities and grammar accuracy. However, participants expressed concern about the potentially diminishing effects on their critical thinking skills due to overreliance on ChatGPT. The implication of the study highlights that the identified correlations between personality traits and specific questionnaire items offer insights into potential usage patterns of ChatGPT among students. This finding implies that teachers should consider exploring ChatGPT as a pedagogical tool, tailoring its integration into teaching materials to align with students’ diverse personalities and learning preferences.