The implementation of the online class by COVID-19 became a revealing period of the various problem in a school science class. However, the application of digital collaboration tools in the class could provide a solution to this problem like as Reduction of learning time, loss of motivation to learn, lack of interaction, the difficulty of concept change and etc. If a teacher applies the digital collaboration tool to his class, he could construct his science class convertible contact class to a non-contact class, In this context, the purpose of this study has focused development of a learning program that applied digital collaboration tools for the concept change of the human brain. The 45 high school students were recruited to attend two types of science classes (face class: 23, not face class: 22). The researchers tested the concept of the human brain, the motivation of biology activity, the motivation of biology learning, and the task commitment of biology learning between pre and post class period. As a result of this study, the concept change learning program of the human brain showed a positive effect on concept change from misconception to scientific concept and affective domain. Also, the effect of this program was statistically significant. Consequently, it could develop an effective learning program of concept change in the human brain to be able to convert the contact class into a non-contact class.